✦ LIBER ✦

The design, synthesis and evaluation of affinity ligands for prion proteins

✍ Scribed by Emma N. Soto Renou; Geeta Gupta; Duncan S. Young; Denise V. Dear; Christopher R. Lowe

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 339 KB
Volume: 17
Category: Article
ISSN: 0952-3499
DOI: 10.1002/jmr.670

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✦ Synopsis

Abstract

Bifunctional affinity ligands based on a triazine scaffold were rationally designed to target prion protein and shown to bind recombinant prion protein with high affinity and selectivity. The ligands were capable of discriminating between prion protein glycoforms and monomeric and dimeric forms of the prion protein. The ligands also discriminate between conformational differences in the prion protein, resulting from point mutations in the prion protein gene. These results suggest that derived compounds could be used selectively to detect the disease‐associated form of the prion protein, and as such, could provide diagnostic or therapeutic tools for prion diseases. Copyright © 2004 John Wiley & Sons, Ltd.

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