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Design, Synthesis, and Biological Evaluation of Non-Peptidic Ligands at the Xenopus laevis Skin-Melanocortin Receptor.

✍ Scribed by Ursula Tammler; J. Mark Quillan; Jochen Lehmann; Wolfgang Sadee; Matthias U. Kassack


Publisher
John Wiley and Sons
Year
2003
Weight
62 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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2,4-disubstituted morpholin-3-one based ligands which show affinity for tachykinin receptors have been designed and synthesised. Variation of the side chains attached to the central template gives rise to selectivity between receptor subtypes. This selectivity is directly analogous to that exhibited