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‘Targeted’ molecular diversity: design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors

✍ Scribed by David Horwell; Martyn Pritchard; Jennifer Raphy; Giles Ratcliffe


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
313 KB
Volume
33
Category
Article
ISSN
0162-3109

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The design and synthesis of non-peptide
✍ David C. Horwell; Andrew I. Morrell; Edward Roberts 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 112 KB

2,4-disubstituted morpholin-3-one based ligands which show affinity for tachykinin receptors have been designed and synthesised. Variation of the side chains attached to the central template gives rise to selectivity between receptor subtypes. This selectivity is directly analogous to that exhibited