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The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury

✍ Scribed by Ophascharoensuk, Vuddhidej; Fero, Matthew L.; Hughes, Jeremy; Roberts, James M.; Shankland, Stuart J.

Book ID: 109928637
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 974 KB
Volume: 4
Category: Article
ISSN: 1078-8956
DOI: 10.1038/nm0598-575

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## Abstract Expression of cyclin dependent kinase (Cdk) inhibitor p27^Kip1^, which blocks cell cycle progression from G~1~ to S phase, can be regulated via multiple mechanisms including transcription, protein degradation, and translation. Recently, it was shown that p27^Kip1^ plays an important rol