## Abstract Expression of cyclin dependent kinase (Cdk) inhibitor p27^Kip1^, which blocks cell cycle progression from G~1~ to S phase, can be regulated via multiple mechanisms including transcription, protein degradation, and translation. Recently, it was shown that p27^Kip1^ plays an important rol
โฆ LIBER โฆ
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
โ Scribed by Kato, Jun-ya; Tomoda, Kiichiro; Kubota, Yukiko
- Book ID
- 109599687
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 498 KB
- Volume
- 398
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/18230
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## Background and objectives: P27kip1 (p27) plays an important role as a negative regulator of cell cycle-dependent kinase activity during progression of the cell cycle. the most important prognosticator of breast cancer is nodal status, and the aim of this study was to determine the prognostic imp