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The conformation of macrolide antibiotics. III. Circular dichroism and the conformation of erythromycins

✍ Scribed by L.A. Mitscher; B.J. Slater; T.J. Perun; P.H. Jones; J.R. Martin

Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
215 KB
Volume
10
Category
Article
ISSN
0040-4039

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✦ Synopsis

Received in USA 1st Mgust ~63; -rec&ved in UK for publication 6th titober 1969) There has been considerable recent interest in the solution conformation of macrolide antibiotics based upon the reasonable expectation that this knowledge would lead to deeper insight into their chemical, physical and biological properties (1,2,3,4). Of the various possibilities put forth for erythromycin, the CD data in this note, the accompanying nmr evidence (41, and earlier X-ray measurements (5) are most consistent with conformation I,.b c f representing the After completion of this manuscript a full account (14) of Demarco's work (3) appeared in which a somewhat modified conformation is presented.

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