The conformation of erythromycin aglycones
β Scribed by Thomas J. Perun; Richard S. Egan
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 232 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
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Received in USA 1st Mgust ~63; -rec&ved in UK for publication 6th titober 1969) There has been considerable recent interest in the solution conformation of macrolide antibiotics based upon the reasonable expectation that this knowledge would lead to deeper insight into their chemical, physical and b
## Abstract A complete and unambiguous assignment of the ^1^H and ^13^C NMR spectra of (__E__)βerythromycin A oxime in acetoneβ__d__~6~ was accomplished by twoβdimensional chemical shift correlation methods. The ^1^H NMR NOE data, in conjunction with molecular modeling techniques, were used to pred
Strong evidence has accumulated in favor of a conformation for the erythronolide rin& the nucleus of the erythromycin antibiotics, which is approximated by the stereoformula L. '-' This and 2, R,+R,= 0 i.1 R,=OH, R3 =H 5, R,=H, R,=OH closely related3 three-dimensional arrangements lie in a deep well