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Structural and conformational analysis of (E)-erythromycin A oxime

✍ Scribed by John M. McGill; Ross Johnson

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
467 KB
Volume
31
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

A complete and unambiguous assignment of the ^1^H and ^13^C NMR spectra of (E)‐erythromycin A oxime in acetone‐d~6~ was accomplished by two‐dimensional chemical shift correlation methods. The ^1^H NMR NOE data, in conjunction with molecular modeling techniques, were used to predict the predominant solution conformation of erythromycin A oxime in acetone‐d~6~. This conformational analysis was used to explain the lack of facial selectivity observed in the reduction of the oxime.

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