Extension of the erythromycin biosynthetic pathway : Isolation and structure of erythromycin E
β Scribed by J.R. Martin; R.S. Egan; A.W. Goldstein; P. Collum
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 474 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4020
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## Abstract A complete and unambiguous assignment of the ^1^H and ^13^C NMR spectra of (__E__)βerythromycin A oxime in acetoneβ__d__~6~ was accomplished by twoβdimensional chemical shift correlation methods. The ^1^H NMR NOE data, in conjunction with molecular modeling techniques, were used to pred
Among the semisynthetlo derivative8 of an importent antibiotio, erythrunytin A, Its cyclic carbonate exhibit8 the unique property of being more active against becteria than the parent antibiotic l,B . In the hypothetical struoture of the canpound pO8tUlated by Eli Lilly group, the substitution by ca