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Circular dichroism and solution conformation of the tetracycline antibiotics.

✍ Scribed by L.A. Mitscher; A.C. Bonacci; T.D. Sokoloski

Publisher: Elsevier Science
Year: 1968
Tongue: French
Weight: 217 KB
Volume: 9
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)75384-6

No coin nor oath required. For personal study only.

✦ Synopsis

It is axiomatic that in circular dichroism studies, knowledge of the absolute configuration allows determination of the conformation, and vice versa (1). The tetracycline antibiotics are -unusually complex from a conformational standpoint, but choice of appropriate conditions allows one to obtain a great deal of useful information from the CD spectra. Hopefully, this information should be useful in understanding structure-activity relationships and physico-chemical properties.

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