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The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

✍ Scribed by Kiyotsugu Yoshida; Yoshio Miki

Book ID: 108586655
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 413 KB
Volume: 101
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2009.01488.x

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## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequence‐specific transcription factor that regula