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Expression of the human tumor suppressor p53 induces cell death in Pichia pastoris

✍ Scribed by Salma Abdelmoula-Souissi; Imed Mabrouk; Ali Gargouri; Raja Mokdad-Gargouri


Book ID
109295816
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
340 KB
Volume
12
Category
Article
ISSN
1567-1356

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Mutations in the p53 tumor suppressor ge
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In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent clonin