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The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death

✍ Scribed by Nikhil S. Chari; Nicole L. Pinaire; Lynnelle Thorpe; L. Jeffrey Medeiros; Mark J. Routbort; Timothy J. McDonnell


Book ID
106349798
Publisher
Springer
Year
2009
Tongue
English
Weight
353 KB
Volume
14
Category
Article
ISSN
1360-8185

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## Abstract Drug resistance remains a key obstacle to successful cancer treatment. The implementation of pharmacogenomics is widely proclaimed as a route to revolutionize the face of cancer therapy. Here we discuss the pharmacogenomics of the p53 tumor suppressor and its role in cancer chemosensiti