Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage
β Scribed by Tanaka, Nobuyuki; Ishihara, Masahiko; Lamphier, Marc S.; Nozawa, Hiroaki; Matsuyama, Toshifumi; Mak, Tak W.; Aizawa, Shinichi; Tokino, Takashi; Oren, Moshe; Taniguchi, Tadatsugu
- Book ID
- 109796735
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 762 KB
- Volume
- 382
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/382816a0
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Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, transduce the signal, and ultimately delay the cell cycle or trigger apoptosis. Recently, we have shown that BTG2/TIS21 gene expression was indu
## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequenceβspecific transcription factor that regula