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The catalytic mechanism of carbonic anhydrase

โœ Scribed by Sven Lindskog


Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
117 KB
Volume
79
Category
Article
ISSN
0020-1693

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Hydrogen Bonds and the Catalytic Mechani
โœ SILKE THOMS ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 142 KB

A new model for catalysis of human carbonic anhydrase II is suggested. The model is based on the X-ray structure of the hydrogen bond network in the catalytic site. The outer part of the network is proposed to adjust the pK a of the catalytic site to the experimentally observed value of about 7. The