The biosynthetic origin of the pyridone ring of efrotomycin
β Scribed by Gary Darland; Byron Arison; Louis Kaplan
- Publisher
- Springer-Verlag
- Year
- 1991
- Tongue
- English
- Weight
- 543 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1476-5535
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The biosynthesis of the tetrahydropyranyl side chain of verucopeptin (1) in cultures of Actinomadura verrucosospora was investigated. Incorporation experiments using 13C-labeled acetate and propionate, followed by analysis of the labeled metabolite by NMR, revealed that the tetrahydropyranyl side ch
\({ }^{13}\)-labeling experiments were performed to determine the simple precursor metabolites that contribute to the tetrapyrrole skeleton of heme \(\mathrm{d}_{1}\). By use of \(5-\left[4^{-13} \mathrm{C}\right]\) aminolevulinic acid it was determined that the skeleton is derived from \(8 \mathrm{