Biosynthetic origin of the tetrahydropyranyl side chain of verucopeptin

✍ Scribed by Youla S. Tsantrizos; Jianhua Shen; Laird A. Trimble

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 238 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01661-4

✦ Synopsis

The biosynthesis of the tetrahydropyranyl side chain of verucopeptin (1) in cultures of Actinomadura verrucosospora was investigated. Incorporation experiments using 13C-labeled acetate and propionate, followed by analysis of the labeled metabolite by NMR, revealed that the tetrahydropyranyl side chain of I is derived from three acetate and five propionate units. A biosynthetic scheme consistent with the observed labeling patterns has been proposed.