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The asymmetric synthesis of Sitagliptin, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

โœ Scribed by Liu, Feng (author);Yu, Wansheng (author);Ou, Wenhua (author);Wang, Xiaoke (author);Ruan, Libo (author);Li, Yiming (author);Peng, Xijiang (author);Tao, Xiaohu (author);Pan, Xianhua (author)

Book ID
118201689
Publisher
Scientific Reviews Ltd.
Year
2010
Tongue
English
Weight
141 KB
Volume
2010
Category
Article
ISSN
0308-2342

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ChemInform Abstract: The Asymmetric Synt
ChemInform Abstract: The Asymmetric Synthesis of Sitagliptin, a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes.
โœ Feng Liu; Wansheng Yu; Wenhua Ou; Xiaoke Wang; Libo Ruan; Yiming Li; Xijiang Pen ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 23 KB ๐Ÿ‘ 1 views

## Abstract Key step in the improved synthetic pathway to sitagliptin (VII), a new DPPโ€IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).