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RBx-0597, a potent, selective and slow-binding inhibitor of dipeptidyl peptidase-IV for the treatment of type 2 diabetes

✍ Scribed by Shuchita Singh; Sachin Sethi; Vivek Khanna; Biju Benjamin; Rajiv Kant; Jitendra Sattigeri; Vinay S Bansal; Pradip Kumar Bhatnagar; Joseph Alex Davis


Book ID
113588838
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
732 KB
Volume
652
Category
Article
ISSN
0014-2999

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ChemInform Abstract: The Asymmetric Synt
✍ Feng Liu; Wansheng Yu; Wenhua Ou; Xiaoke Wang; Libo Ruan; Yiming Li; Xijiang Pen πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 23 KB πŸ‘ 1 views

## Abstract Key step in the improved synthetic pathway to sitagliptin (VII), a new DPP‐IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).