An efficient asymmetric synthesis in nine steps of natural (À)-pumiliotoxin C (1), a decahydroquinoline alkaloid found in the skin of Central American frog species, is presented. The enantiomerically pure starting material (S)-norvalinol (3), obtained from commercial (S)-norvaline, was cyclized in a
✦ LIBER ✦
The Asymmetric Synthesis of (-)-Pumiliotoxin C Using Tandem Catalysis.
✍ Scribed by Ewold W. Dijk; Lavinia Panella; Pedro Pinho; Robert Naasz; Auke Meetsma; Adriaan J. Minnaard; Ben L. Feringa
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 9 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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