Bifunctional Asymmetric Catalysis: A Tandem Nucleophile/Lewis Acid Promoted Synthesis of β-Lactams.
✍ Scribed by Stefan France; Harald Wack; Ahmed M. Hafez; Andrew E. Taggi; Daniel R. Witsil; Thomas Lectka
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The present, efficient protocol for catalytic asymmetric cyclocondensation of acyl halides with aldehydes is based on combination of Lewis acid and organic aprotic ion pair catalysis in an single catalyst system.
Ease of generation, stablity in solution at ambient temperature, high enantioselectivity in Diels-Alder reactions, efficient catalyst recovery, and large rate differences on variation of the anion are all characteristics of the new Ru Lewis acid [CpRu((S,S)-biphop-F)] (biphop-F=(C F ) POCH (Ph)CH (P