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The applications of near-infrared Fourier transform Raman spectroscopy to the analysis of polymorphic forms of cimetidine

✍ Scribed by A.M. Tudor; M.C. Davies; C.D. Melia; D.C. Lee; R.C. Mitchell; P.J. Hendra; S.J. Church

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 369 KB
Volume: 47
Category: Article
ISSN: 1386-1425
DOI: 10.1016/0584-8539(91)80229-c

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✦ Synopsis

Ahatraet-Fourier transform (lT)-Raman spectroscopy, utilizing a near-infrared (Nd:YAG laser, at 1.064pm) source was used to characterise the three anhydrous polymorphic forms A, B and C of the drug cimetidine (N"-cyano-N-methyl-N'-[2-[(5-methyl-l~-imidaxol-4-yl) methylthio]ethyl]guanidine). The FT-Raman spectra were free from fluorescence interference and had good signal-to-noise ratios. Each polymorph has a distinct spectrum, characterised by two regions, 1250-105Ocm-' and 1500-135Ocm-'. This work demonstrates that it is possible to use FT-Raman spectroscopy to differentiate between polymorphic forms of the same compound.

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