## Abstract We analyzed the adenomatous polyposis coli (__APC__) tumorsuppressor gene as one of the possible genes mutated in human pancreatic carcinomas. DNAs from 39 surgical specimens were subjected to singleβstrand conformation polymorphism analysis of polymerase chain reaction products and the
The adenomatous polyposis coli gene and human cancers
β Scribed by Yusuke Nakamura
- Book ID
- 112496770
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 738 KB
- Volume
- 121
- Category
- Article
- ISSN
- 1432-1335
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We report the genomic cloning and sequence analysis of a novel and (so far) smallest coding exon of the human adenomatous polyposis coli (APC) gene. This additional exon of 54 nucleotides in length, designated APC exon 10A, is located 1.6 kb downstream from exon 10. It resides on a 0.5-kb genomic Ec
Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene p