Hypermethylation of the APC (adenomatous
β
Mikko O. Hiltunen; Leena Alhonen; Jari Koistinaho; Sanna MyâhÀnen; Matti PÀÀkkân
π
Article
π
1997
π
John Wiley and Sons
π
French
β 206 KB
π 2 views
Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o