Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype
β Scribed by Van der Auwera, I; Van Laere, S J; Van den Bosch, S M; Van den Eynden, G G; Trinh, B X; van Dam, P A; Colpaert, C G; van Engeland, M; Van Marck, E A; Vermeulen, P B
- Book ID
- 109999800
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 225 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Promoter hypermethylation is a major mechanism for gene silencing and offers a promising starting point for developing molecular biomarkers. The purpose of our study was to determine aberrant methylation of the adenomatous polyposis coli (__APC__) gene promoter 1A with respect to its pr
Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T