Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o
Methylation of the adenomatous polyposis coli (APC) gene in human placenta and hypermethylation in choriocarcinoma cells
β Scribed by N.C. Wong; B. Novakovic; B. Weinrich; C. Dewi; R. Andronikos; M. Sibson; F. Macrae; R. Morley; M.D. Pertile; J.M. Craig; R. Saffery
- Book ID
- 116334764
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 308 KB
- Volume
- 268
- Category
- Article
- ISSN
- 0304-3835
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## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm