Alterations of Adenomatous Polyposis Coli (APC) gene in oral squamous cell carcinoma
β Scribed by Kuo-Wei Chang; Shu-Chun Lin; Kathy A. Mangold; Ming-Shan Jean; Ta-Chun Yuan; Shue-Ni Lin; Che-Shoa Chang
- Book ID
- 117610305
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 593 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0901-5027
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Recent studies have suggested that abnormalities in the adenomatous polyposis coli gene (AP C gene) are associated with the development not only of familial adenomatous polyposis coli (FAP) but also of cancers in digestive organs. In order to elucidate whether abnormalities of the APC gene could con
Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o