The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma
✍ Scribed by Mario Pérez-Sayáns; José Manuel Suárez-Peñaranda; Michel Herranz-Carnero; Pilar Gayoso-Diz; Francisco Barros-Angueira; José Manuel Gándara-Rey; Abel García-García
- Book ID
- 113834110
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 350 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1368-8375
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Recent studies have suggested that abnormalities in the adenomatous polyposis coli gene (AP C gene) are associated with the development not only of familial adenomatous polyposis coli (FAP) but also of cancers in digestive organs. In order to elucidate whether abnormalities of the APC gene could con
Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene p