Analyzing the methylation status and expression of adenomatous polyposis coli (APC) gene in lung cancer cell line
β Scribed by Shiyang Pan
- Book ID
- 117981679
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 42 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0753-3322
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A decrease in the intracellular concentrations of the transcripts for some tumor suppressor genes has been found during murine lung tumorigenesis; for p15 INK4b and p16 INK4a , this was due to homozygous deletions. We report here a decrease in the mRNA levels of the mutated in colorectal cancer (Mcc
## Abstract This research assessed the importance of the adenomatous polyposis coli (APC) tumor suppressor mutation in the ability of apigenin to induce cell cycle arrest using HT29βAPC cells, which contain inducible wildβtype APC under the metallothionein promoter. HT29βGAL cells, containing Ξ²βgal
Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T