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TGF-β signalling through the Smad pathway

✍ Scribed by Joan Massaous; Akiko Hata


Book ID
114323107
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
765 KB
Volume
7
Category
Article
ISSN
0962-8924

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Two major Smad pathways in TGF-β superfa
✍ Keiji Miyazawa; Masahiko Shinozaki; Takane Hara; Toshio Furuya; Kohei Miyazono 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 495 KB

Members of the transforming growth factor‐β (TGF‐β) superfamily bind to two different serine/threonine kinase receptors, i.e. type I and type II receptors. Upon ligand binding, type I receptors specifically activate intracellular Smad proteins. R‐Smads are direct substrates of type I receptors; Smad