Non-Smad pathways in TGF-β signaling
✍ Scribed by Zhang, Ying E
- Book ID
- 109846881
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 884 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0007-0610
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Members of the transforming growth factor‐β (TGF‐β) superfamily bind to two different serine/threonine kinase receptors, i.e. type I and type II receptors. Upon ligand binding, type I receptors specifically activate intracellular Smad proteins. R‐Smads are direct substrates of type I receptors; Smad
TGFbeta signaling plays a central role in regulating a broad range of cellular responses in a variety of organisms. TGFbeta signaling from the cell membrane to the nucleus is mediated by the Smad family of proteins. During the past five years of intense investigation, key events in TGFbeta signaling