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Tetrakis(dimethylamino)ethylene as a Useful Reductant of Some Bromodifluoromethyl Heterocycles. Application to the Synthesis of New gem -Difluorinated Heteroarylated Compounds

✍ Scribed by Burkholder, Conrad; Dolbier, William R.; Médebielle, Maurice

Book ID
127296365
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
370 KB
Volume
63
Category
Article
ISSN
0022-3263

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Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones 1-3. The generated ~,~-difluoroacetyl anion was trapped with several aldehydes 4-7, under mild conditions, to give the corresponding 2,2-difiuoro-3-hydroxy ketone derivatives 8-13, in mo

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Tetrakis(dimethylamino)ethylene (TDAE) as a Useful Reductant of Some Chlorodifluoromethylated Ketones. A New Approach for the Synthesis of α,α-Difluoroketone Derivatives. -Reduction of chlorodifluoromethylated ketones with TDAE as an effective reductant generates α,α-difluoroacetyl anions, which ar