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Tetrakis(dimethylamino)ethylene (TDAE) as a useful reductant of some chlorodifluoromethylated ketones. A new approach for the synthesis of α,α-difluoroketone derivatives

✍ Scribed by Conrad Burkholder; William R. Dolbier Jr; Maurice Me´debielle; Alexandre Ndedi

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
237 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones 1-3. The generated ~,~-difluoroacetyl anion was trapped with several aldehydes 4-7, under mild conditions, to give the corresponding 2,2-difiuoro-3-hydroxy ketone derivatives 8-13, in moderate yields.

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ChemInform Abstract: Tetrakis(dimethylam
ChemInform Abstract: Tetrakis(dimethylamino)ethylene (TDAE) as a Useful Reductant of Some Chlorodifluoromethylated Ketones. A New Approach for the Synthesis of α,α-Difluoroketone Derivatives.
✍ C. BURKHOLDER; W. R. JUN. DOLBIER; M. MEDEBIELLE; A. NDEDI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Tetrakis(dimethylamino)ethylene (TDAE) as a Useful Reductant of Some Chlorodifluoromethylated Ketones. A New Approach for the Synthesis of α,α-Difluoroketone Derivatives. -Reduction of chlorodifluoromethylated ketones with TDAE as an effective reductant generates α,α-difluoroacetyl anions, which ar