## Abstract We applied linkage analysis with a sibβpair method, which also takes into account information on unaffected siblings, and familyβbased methods of association analysis to determine the disease affecting loci in Problem 1. Whereas the first two disease loci were correctly identified by as
β¦ LIBER β¦
Tests for Linkage and Association in Nuclear Families
β Scribed by E.R. Martin; N.L. Kaplan; B.S. Weir
- Book ID
- 117855074
- Publisher
- American Society of Human Genetics
- Year
- 1997
- Tongue
- English
- Weight
- 143 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/514860
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The development of a new method for testing the association of genetic markers with disease is presented. This approach is applicable when sampling nuclear families with one or more affected siblings and when neither, one, or both parents are missing marker genotype data. All siblings, affected and