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Screening for linkage and association in nuclear families

✍ Scribed by Dr. M. Knapp; M. Durner; M. P. Baur

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 283 KB
Volume: 12
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370120616

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We applied linkage analysis with a sib‐pair method, which also takes into account information on unaffected siblings, and family‐based methods of association analysis to determine the disease affecting loci in Problem 1. Whereas the first two disease loci were correctly identified by association analysis, the sib‐pair linkage method failed to detect the disease loci 3 and 4. We therefore determined the data structure and sample size necessary for demonstrating linkage to these loci. ©1995 Wiley‐Liss, Inc.

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