𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Combined linkage and linkage disequilibrium mapping for genome screens

✍ Scribed by Momiao Xiong; Li Jin

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
142 KB
Volume
19
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

Linkage analysis and association studies, two major approaches for genetic studies of human diseases, are useful for mapping genes that are highly penetrant, but both use only part of the information that is available for mapping disease genes. Therefore, they provide limited utility when used alone. In this report, we present combined linkage and linkage disequilibrium mapping that simultaneously utilizes linkage and linkage disequilibrium information for mapping human disease genes. Compared with the existing linkage analysis and association study methods, this method has several advantages: 1) it has high statistical power by a joint analysis of linkage and linkage disequilibrium for localizing disease susceptibility loci: 2) it unifies the theory of linkage analysis and linkage disequilibrium mapping, 3) it retains the general framework for linkage analysis and, hence, can be easily incorporated into the existing software for the linkage analysis. The proposed LLDM is applied to familial hemophagocytic lymphohistiocytosis (FHL) disease.

πŸ“œ SIMILAR VOLUMES

Multipoint linkage disequilibrium mappin
Multipoint linkage disequilibrium mapping approach: Incorporating evidence of linkage and linkage disequilibrium from unlinked region
✍ Fang-Chi Hsu; Kung-Yee Liang; Terri H. Beaty πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 176 KB

## Abstract Gene mapping for complex diseases is still a challenge in genetic studies. For family‐based studies, the single‐locus methods for detecting linkage and linkage disequilibrium (LD) one at a time may not capture the assumed interaction between multiple causal genes efficiently. We propose

An efficient, robust and unified method
An efficient, robust and unified method for mapping complex traits (III): Combined linkage/linkage-disequilibrium analysis
✍ Zhao, Lue Ping ;Quiaoit, Fil ;Aragaki, Corinne ;Hsu, Li πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 196 KB πŸ‘ 1 views

Extending the method for linkage analysis [Zhao et al., 1998a: Am. J. Med. Genet. 77:366-383; 1998b: Am. J. Med. Genet. 79:49-61], this article describes a method for the linkage-disequilibrium analysis, and for combining linkage and linkage-disequilibrium analyses. As highly dense markers are incre

Multipoint linkage disequilibrium mappin
Multipoint linkage disequilibrium mapping for complex diseases
✍ Kung-Yee Liang; Fang-Chi Hsu; Terri H. Beaty πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 107 KB

## Abstract Linkage disequilibrium (LD) or association studies using case‐parent trios have become a common approach to locate unobserved susceptibility genes underlying complex diseases. With the availability of ever more dense marker maps, how to utilize the information carried by multiple marker

Fieller's theorem and linkage disequilib
Fieller's theorem and linkage disequilibrium mapping
✍ Heather J. Cordell; Robert C. Elston πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

Linkage disequilibrium mapping exploits the fact that at genetic markers close enough to a disease locus on a particular chromosome, we expect to find an association between the disease and marker alleles. Furthermore, the magnitude of the association is expected to follow a unimodal curve when plot

Linkage disequilibrium mapping with geno
Linkage disequilibrium mapping with genotype data
✍ Shuanglin Zhang; Hongyu Zhao πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 48 KB

## Abstract Linkage disequilibrium mapping has proven a powerful tool for locating disease genes. Although all existing linkage disequilibrium mapping methods implicitly assume that individual haplotypes can be inferred, only genotypes are directly observable in practice, and haplotypes cannot alwa