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Linkage disequilibrium mapping with genotype data

โœ Scribed by Shuanglin Zhang; Hongyu Zhao

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
48 KB
Volume
22
Category
Article
ISSN
0741-0395

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โœฆ Synopsis

Abstract

Linkage disequilibrium mapping has proven a powerful tool for locating disease genes. Although all existing linkage disequilibrium mapping methods implicitly assume that individual haplotypes can be inferred, only genotypes are directly observable in practice, and haplotypes cannot always be uniquely resolved based on genotype data. In this article, we propose a likelihoodโ€based linkage disequilibrium mapping approach to analyzing multilocus genotype data arising from caseโ€control studies. Results from extensive simulation studies suggest that this approach may be a useful tool to fine map disease genes using caseโ€control data. Genet. Epidemiol. 22:66โ€“77, 2002. ยฉ 2002 Wileyโ€Liss, Inc.

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