A Test of Linkage for Complex Discrete and Continuous Traits in Nuclear Families
β Scribed by David Tritchler; Ying Liu; Shafagh Fallah
- Book ID
- 110693684
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 184 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0006-341X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract This paper presents a unified framework for transmissionβdisequilibrium tests for discrete and continuous traits. A conditional score test is derived that maximizes power to detect small effects for any exponential family distribution, which includes binary and normal distributions, and
## Abstract We present a unified approach to selection and linkage analysis of selected samples, for both quantitative and dichotomous complex traits. It is based on the score test for the variance attributable to the trait locus and applies to general pedigrees. The method is equivalent to regress
We investigated the statistical properties of a variance components method for quantitative trait linkage analysis using nuclear families and extended pedigrees.
A more powerful robust test for linkage is developed from the methodology of Haseman and Elston [Behav Genet 2(1):3-19, 19721. This new robust test uses weighted least-squares (WLS) methods to detect linkage between a quantitative trait and a polymorphic marker. For comparison, the characteristics o