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Temperature Sensitive Mutant Mammalian Cells

Book ID
109684423
Publisher
Nature Publishing Group
Year
1972
Tongue
English
Weight
133 KB
Volume
240
Category
Article
ISSN
0028-0836

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## Abstract Mammalian cell populations may be enriched for temperature‐sensitive (__ts__) mutants by the tritiated thymidine (^3^H‐TdR) suicide procedure (Thompson et al., '71). Such procedures were carried out on the near‐diploid Chinese hamster ovary (CHO) cell line and on a line made β€œtetraploid

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The temperature-sensitive (ts) Chinese hamster ovary (CHO) cell mutant tsHl contains a therrnolabile leucyl-tRNA synthetase. Upon incubation at the nonpermissive temperature of 39.5"C, the enzyme became reversibly inhibited over a period of minutes, and the cells lost viability over a period of many