Telomeres and telomerase in ageing and cancer
โ Scribed by John K. Cowell
- Publisher
- Springer Netherlands
- Year
- 1999
- Tongue
- English
- Weight
- 624 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0161-9152
No coin nor oath required. For personal study only.
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Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de now by telomerase, an unusua
Telomeres are guanine-rich regions that are located at the ends of chromosomes and are essential for preventing aberrant recombination and protecting against exonucleolytic DNA degradation. Telomeres are maintained by telomerase, an RNA-dependent DNA polymerase. Because telomerase is known to be exp
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## Abstract The telomeric checkpoint is emerging as a critical sensor of cellular damage, playing a major role in human aging and cancer development. In the meantime, telomere biology is rapidly evolving from a basic discipline to a translational branch, capable of providing major hints for biomark