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Telomeres and telomerase in normal and malignant B-cells

✍ Scribed by Chiara Lobetti-Bodoni; Elisa Bernocco; Elisa Genuardi; Mario Boccadoro; Marco Ladetto

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
219 KB
Volume
28
Category
Article
ISSN
0278-0232

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✦ Synopsis

Abstract

The telomeric checkpoint is emerging as a critical sensor of cellular damage, playing a major role in human aging and cancer development. In the meantime, telomere biology is rapidly evolving from a basic discipline to a translational branch, capable of providing major hints for biomarker development, risk assessment and targeted treatment of cancer. These advances have a number of implications in the biology of lymphoid tumours. Moreover, there is considerable interest in the potential role of telomeric dysfunction in the wide array of immunological abnormalities, grouped under the definition of β€˜immunosenescence’. This review will summarize the impact of recent advances in telomere biology on the physiology and pathology of the B lymphocyte, with special interest in immunosenescence and lymphomagenesis. Copyright Β© 2010 John Wiley & Sons, Ltd.

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