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Telomeres and telomerase: A dual role in hepatocarcinogenesis

โœ Scribed by Ande Satyanarayana; Michael P. Manns; K. Lenhard Rudolph

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
201 KB
Volume
40
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

โœฆ Synopsis

Telomere shortening limits the proliferative capacity of primary human cells and restrains the regenerative capacity of organ systems during chronic diseases and aging. Telomere shortening apparently has a dual role in tumor development and progression. On the one hand, it induces chromosomal instability and the initiation of cancer; on the other hand, tumor progression requires stabilization of telomeres. The predominant mechanism of telomere stabilization in tumor cells is the activation of the telomere-synthesizing enzyme telomerase. The potential use of telomerase activators for the treatment of regenerative disorders will ultimately depend on their effects on tumorigenesis. This review focuses on the role of telomere shortening and telomerase in carcinogenesis with a special focus on hepatocellular carcinoma.

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