๐”– Bobbio Scriptorium
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Telomeres, telomerase and senescence

โœ Scribed by Carol W. Greider

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
823 KB
Volume
12
Category
Article
ISSN
0265-9247

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โœฆ Synopsis

Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de now by telomerase, an unusual DNA polymerase. Telomerase is an RNP in which an essential RNA component provides the template for the added telomere repeats. Telomere length maintenance plays an essential role in cell viability.

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