## BACKGROUND. Telomerase is an enzyme that adds repeated telomere sequences to the ends of chromosome arms. It helps maintain both the length of telomere and infinite cell proliferation. In recent years, telomerase activity has been considered an important characteristic that differentiates betwe
Telomerase activity in the differentiation of benign and malignant adrenal tumors
โ Scribed by Lisong Teng; Olga Tucker; Carl Malchoff; E.Darracott Vaughan Jr; Jessica Jacobson; Thomas J. Fahey III
- Book ID
- 117849046
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 35 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0039-6060
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## BACKGROUND. Telomerase is a ribonucleoprotein that maintains telomeric base pair repeats at the ends of mammalian chromosomes during DNA replication. Telomerase is expressed in various human tumors, some normal tissues, and immortalized cell lines. The assay of telomerase activity has potentia
Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomeraseassociated protein (TP1) and human telomerase catalytic subunit (hTERT), have