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Telomerase activity as an indicator of potentially malignant adrenal tumors

✍ Scribed by Yasuhiro Hirano; Kimio Fujita; Kazuo Suzuki; Tomomi Ushiyama; Yoshihisa Ohtawara; Fumio Tsuda

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 85 KB
Volume: 83
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19980815)83:4<772::aid-cncr21>3.0.co;2-o

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✦ Synopsis

BACKGROUND.

Telomerase is an enzyme that adds repeated telomere sequences to the ends of chromosome arms. It helps maintain both the length of telomere and infinite cell proliferation. In recent years, telomerase activity has been considered an important characteristic that differentiates between normal and cancerous cells. Because the authors often encountered difficulties in distinguishing between benign and malignant adrenal tumors, they investigated whether the expression of telomerase activity could distinguish potentially malignant adrenal tumors.

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