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Telomerase activity as an indicator of malignant potential in iodine-nonreactive lesions of the esophagus

✍ Scribed by Kazuo Koyanagi; Soji Ozawa; Nobutoshi Ando; Makio Mukai; Yuko Kitagawa; Masakazu Ueda; Masaki Kitajima

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 219 KB
Volume: 88
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(20000401)88:7<1524::aid-cncr4>3.0.co;2-6

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✦ Synopsis

BACKGROUND.

Iodine-nonreactive lesions of esophageal epithelium often are associated with dysplasia and carcinoma. The authors examined the usefulness of telomerase activity as an indicator for esophageal carcinogenesis in such lesions.

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## BACKGROUND. Telomerase is an enzyme that adds repeated telomere sequences to the ends of chromosome arms. It helps maintain both the length of telomere and infinite cell proliferation. In recent years, telomerase activity has been considered an important characteristic that differentiates betwe