TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells
✍ Scribed by Marta Catalfamo; Xuguang Tai; Tatiana Karpova; James McNally; Pierre A. Henkart
- Book ID
- 108782313
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 719 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0019-2805
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## Abstract To evaluate the __in vivo__ effect of immunosuppressive glucocorticoids on CD4^+^CD25^+^ T regulatory cells, we injected dexamethasone (Dex) into BALB/c mice. Administrationof Dex enhanced the proportion of CD4^+^CD25^+^ cells and the ratio of CD4^+^CD25^+^ cells to CD4^+^CD25^–^ cells
## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut