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Role of TCR specificity in CD4+CD25+ regulatory T-cell selection

✍ Scribed by Cristina Cozzo Picca; Joseph Larkin III; Alina Boesteanu; Melissa A. Lerman; Andrew L. Rankin; Andrew J. Caton

Book ID
110746669
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
406 KB
Volume
212
Category
Article
ISSN
0105-2896

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## Abstract Although the phenotypic and regulatory properties of the CD4^+^CD25^+^ T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4^+^CD25^+^ Treg population includes the recognition of a broad spectrum of human TCR CDR