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Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression

✍ Scribed by Brigitte Birebent; Richard Lorho; Hélène Lechartier; Sophie de Guibert; Mehdi Alizadeh; Nicolas Vu; Alain Beauplet; Nelly Robillard; Gilbert Semana

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
374 KB
Volume
34
Category
Article
ISSN
0014-2980

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## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut