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CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice

✍ Scribed by Paula Kolar; Karin Knieke; J. Kolja E. Hegel; Dagmar Quandt; Gerd-R. Burmester; Holger Hoff; Monika C. Brunner-Weinzierl

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
231 KB
Volume
60
Category
Article
ISSN
0004-3591

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Distinct roles of CTLA-4 and TGF-β in CD
Distinct roles of CTLA-4 and TGF-β in CD4+CD25+ regulatory T cell function
✍ Qizhi Tang; Elisa K. Boden; Kammi J. Henriksen; Helene Bour-Jordan; Mingying Bi; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB

## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut